Iran’s defence minister Aziz Nasirzadeh and army chief Abdolrahim Mousavi were killed in the US-Israel joint attacks following the death of Tehran’s supreme leader Ayatollah Ali Khamenei (Credit: Abhishek Mitra)

US-Israel Attacks Iran Live News Updates: The Middle East has entered a state of unprecedented escalation following the confirmed killing of Iran’s Supreme Leader, Ayatollah Ali Khamenei, in joint US-Israeli airstrikes. As “Operation Epic Fury” moves into a critical new phase, the conflict has spilled over into neighbouring nations, sparking deadly unrest and regional retaliation.

Here are latest developments:

• Arafi to lead temporarily: Ayatollah Arafi has been named to lead Iran temporarily, Khaleej Times reported. Arafi, a seasoned cleric and close associate of Khamenei, Arafi currently serves as deputy chairman of the Assembly of Experts.
• Violence in Pakistan: At least six people have been killed in Karachi after protesters stormed the US Consulate in response to the killing of Khamenei. Local authorities report the situation is currently under “control” but remains volatile.
• Leadership vacuum in Tehran: In addition to the Supreme Leader, CNN reports the deaths of Iran’s Defense Minister and the Chief of Staff of the Armed Forces, Lt. Gen. Abdolrahim Mousavi.
• Regional retaliation: Iran has launched a massive wave of drone and missile strikes. Explosions have been reported for a second consecutive day in Dubai, Abu Dhabi, and Doha.
• Trump’s warning: President Donald Trump has confirmed the death of Khamenei, warning Tehran that any further retaliation will be met with “a force that has never been seen before”.
• Humanitarian toll: The Iranian Red Crescent reports over 201 fatalities nationwide, including a strike on a girls’ school in southern Iran with at least 85 feared dead.
• Airport Disruptions in Gulf: Major flight cancellations reported at Kuwait, Abu Dhabi, and Dubai airports due to ongoing drone activity and interceptions by Saudi and Jordanian defences.

Our analysis: The targeting of Iran’s highest political and military symbols marks the total collapse of nuclear diplomacy.

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